LRRK2 and Parkinson disease: Kinase inhibition has been shown to induce S1292 dephosphorylation in vivo and in vitro, several PD-linked mutations enhance this phosphorylation, and kinase-dead LRRK2 is not phosphorylated at this residue.14 However, to date, detection of pS1292 has only been possible in models of LRRK2 overexpression in mice14 or in urine after exosome enrichment in humans15 but not at endogenous levels in tissue.