We hypothesize that the beneficial effect of EET-agonists on cardiac function is mediated by a reduction in the local secretion of inflammatory molecules such as NOV by pericardial fat, accompanied by upregulation of PGC-1α and HO-1 and amelioration of obesity-mediated cardiomyopathy. This evidence concerns the gene HMOX1 and obesity due to melanocortin 4 receptor deficiency.