In light of the finding that chronic inflammation is an important histopathologic feature in AD, recent studies have revealed that the stimulation of human primary astrocytes or the astrocytoma cell line U373 with IFNγ and TNFα or IFNγ and IL-1β triggered the production of Aβ1–40 and Aβ1–42. Here, IFNG is linked to Alzheimer disease.