APP and Alzheimer disease: Emerging evidence supports that an interaction between the amino terminal (NH(2))-derived tau fragment of the human tau40 isoform and APP is closely associated with mitochondrial adenine nucleotide translocator-1 (ANT-1) and cyclophilin D. The two peptides inhibit the ANT-1 dependent adenosine diphosphate adenosine triphosphate (ADP/ATP) exchange and exacerbate mitochondrial dysfunction and synaptic deterioration in AD pathology [8].