The average levels of HOTAIR expression in cardiac tissues of patients with CHDs and patients with RVHDs as well as in plasma of the ASD group, the VSD group, the PDA group, and the normal group were (0.111 ± 0.015), (0.055 ± 0.007), (1.37 ± 0.42), (1.39 ± 0.60), (1.35 ± 0.57), and (1.00 ± 0.33), respectively. Here, HOTAIR is linked to Patent ductus arteriosus.