IGFBP2 and osteosclerosis: There is very little data on the expression and activity of any of the IGFBP gene family in dental tissues, however, the involvement of IGFBP-2 in enhanced osteogenesis was suggested by the observation of skeletal thickening associated with elevated serum IGFBP-2 levels in hepatitis-associated osteosclerosis (Khosla et al., 1998).