Consensus regarding gender as a risk factor for renal dysfunction could not be arrived at, as some studies found women to be at greater risk,19,26 while others found men to be at greater risk.20 Older age has been documented in numerous studies including ours as a risk factor for renal impairment.19,20,27 A low CD4 count, high viral load and low haemoglobin are other variables found to be associated with a lower eGFR.12,19,20,27 In our study, despite having a mean CD4 of 177 cells/μL, a CD4 threshold of < 200 cells/μL was insignificant as a risk factor for renal impairment. This evidence concerns the gene CD4 and Abnormal renal physiology.