CASP3 and chronic myelogenous leukemia, BCR-ABL1 positive: Thus, KPT-330 inhibited CML cell growth, triggered cell cycle arrest and apoptosis by entrapping BCR-ABL and P27 in the nucleus, inhibiting the activities of oncogenes like AKT and activating tumor suppress protein like STAT1 and apoptosis inducer caspase-3 (Figure 3).