Buchheitet al. report that in aspirin exacerbated respiratory disease (AERD), a subtype of CRS/asthma which manifests with recurrent polyposis, CRS, asthma, and non-steroidal anti-inflammatory drug (NSAID) sensitivity, TSLP also drove prostaglandin D2 (PGD2) production from mast cells and was increased in active form in local polyp tissue, thus contributing to the inflammatory cascade10. Here, TSLP is linked to congenital rubella syndrome.