In conclusion, results suggest that theMORT gene is one of the most common epigenetic aberrations seen in human cancer.  Coupled with the timing ofMORT gene silencing duringin vitro epithelial cell immortalization and its occurrence early in the temporal arc of human carcinogenesis, this provides strong circumstantial evidence for a tumor suppressor role for MORT. This evidence concerns the gene ZNF667-AS1 and cancer.