CD274 and neoplasm: Immunotherapeutic approaches include: vaccines which could be classified, according to their sensitization target, in: whole tumor vaccines, tumor-associated antigens and tumor-specific antigens; cell-based therapies, which consist of the administration to the patients of effector immune cells, already sensitized and activated against tumor targets; and immune checkpoint modulators, which consist of antibodies blocking inhibitory immune checkpoint molecules, such as PD-1 and PDL1 [74].