Dou et al. [90] showed that pre-administration of naringen significantly reduced the severity of colitis and resulted in downregulation of pro-inflammatory mediators such as iNOS, intercellular adhesion molecule-1 (ICAM-1), MCP-1, COX-2, TNF-α and IL-6 in the colon mucosa. The gene discussed is ICAM1; the disease is colitis.