This exciting data provides a wide-open opportunity to determine whether induced CXCR3 expression on Tregs by the natural TS compound: 1) Limits the effectiveness of peripheral (colorectal) CXCR3 inhibition; 2) Whether CXCR3 ligands released from antigen presenting cells (APCs) attract CXCR3+ Teffs to the TME; 3) Further activating CXCR3 ligands (CXCL9 and CXCL10) to eradicate tumor cells and suppress the severity of colorectal cancer. Here, CXCR3 is linked to colorectal cancer.