ETBF triggers colitis and strongly induces colonic tumors in multiple intestinal neoplasia (MIN) by Stat3 activation with colitis characterized by a selective T helper type 17 (Th17) response distributed between CD4+ T cell receptor-α/ β (TCR α/ β)+ and CD4/8-TCRγ/ δ+ T cells [35]. The gene discussed is TRGC1; the disease is colitis.