Chromophobe renal cell carcinoma had increased expression of the following KLKs: KLK1 (32-fold), KLK2 (12-fold), KLK3 (69-fold), KLK4 (234-fold), KLK15 (132-fold), whereas decreased expression of KLK5 (5-fold), KLK6 (13-fold), and KLK7 (26-fold). This evidence concerns the gene KLK2 and chromophobe renal cell carcinoma.