With regards to colon adenocarcinoma and thyroid carcinoma, the following KLKs were significantly elevated: KLK6 (106-fold and 12-fold), KLK7 (19-fold and 24-fold), KLK10 (15-fold and 31-fold), KLK11 (4-fold and 20-fold), KLK12 (3-fold and 5-fold), while the following KLKs were significantly downregulated: KLK1 (4-fold and 7-fold), KLK3 (4-fold and 3-fold), KLK15 (6-fold and 6-fold). This evidence concerns the gene KLK1 and colon adenocarcinoma.