Renal clear cell carcinoma had six KLKs in which increased expression was associated with overall survival (KLK2: HR = 1.69; KLK4: HR = 1.63; KLK8: HR = 1.71; KLK10: HR = 2.12; KLK11: HR = 1.76; and KLK14: HR = 1.86). The gene discussed is KLK8; the disease is clear cell renal carcinoma.