CAD and neoplasm: Indeed, the intratumour area of necrosis was smaller in ASA+Cl-treated mice (Figure 4), suggesting better tumour perfusion concomitantly with induction of VM, as evidenced by higher number of PAS+CD31- pixels (Figure 3A-3F) and higher levels of VE-CAD and Slpi considered as molecular markers of VM [22, 25, 26] (Figure 3H).