ESR1 and neoplasm: Univariate analysis demonstrated significant association between improved disease-free survival and low AKT phospho-Ser473 (P = 0.02), high ERα phospho-Ser167 (P = 0.02) and the presence of PIK3CA mutations (P = 0.02), as well as negative lymph node status (P = 0.04), low tumor grade (P = 0.01) and low Ki67 LI (P < 0.001).