VEGFA and neoplasm: Considering our present findings and the good safety and efficacy profiles of the combination of capecitabine and bevacizumab in phase III trials [4, 28], the observed partial effect of capecitabine on the restoration of anti-angiogenesis and inhibition of tumor growth during anti-VEGF treatment suggests more study may enable further optimization of anti-VEGF therapy to provide greater clinical benefit.