Furthermore we know that although the high level of PD-L1 expression, oncogene-addicted NSCLC are associated with a very low tumor mutational burden [22] and a non-inflamed tumor microenvironment, and are characterized by neither an immune response nor a T-cell tumor infiltration [19, 23], thus less likely to respond to immunotherapy [23, 24]. This evidence concerns the gene CD274 and non-small cell lung carcinoma.