CRP and cancer: When all samples were considered, CA19-9 (P = 0.002), ALP (P = 0.006), GGT (P = 0.039) and CRP (P = 0.0007) were significantly elevated in BTC pre-diagnosis samples compared to cancer-free controls, as was the proportion of samples with CA19-9 levels > 37 U/mL (P = 0.038) (Supplementary Table 2).