BRCA2 and ovarian cancer: Furthermore, although point mutations and large rearrangements in the BRCA2 gene giving rise to exon 3 skipping at the mRNA level might be associated to the abnormal phenotype in breast/ovarian cancer families, the skipping of exon 3 does not alter the reading frame, and the RAD51 binding sites, nuclear localization signals in the 3’ region of BRCA2 or other functional domains of the protein still remain intact.