To exclude an a priori resistance to ABT-199 by mutations in ASXL1, RUNX1, TP53 or EZH2, we analysed gene expression data in an extended cohort of MDS patients (n = 90) with or without an adverse mutational profile and compared it to healthy controls (n = 110) (Figure 1). Here, RUNX1 is linked to myelodysplastic syndrome.