KCNE1 and Hyperglycemia: Per sè hyperglycemia inhibits the rapid component of heart delayed rectifier K+ current (Iks), regulating the macromolecular complex formed by Potassium Voltage-Gated Channel Subfamily Q member 1 (KCNQ1 or Kv7.1) and Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 1 (KCNE1) [9] mainly responsible for QT interval duration in normal myocytes [10].