In order to gain insights into the molecular targets of BF-5m we translated the previous above observation on cultured embryonic rat heart ventricle H9c2 cells under high glucose stimulus and show here that the ALR2 inhibitor BF-5m is able to increase cell viability, by reducing the cytotoxic effects induced by hyperglycemia. This evidence concerns the gene AKR1B1 and Hyperglycemia.