NOX4 and liver dysplastic nodule: miR-25 is downregulated in both human and experimental DN, and this deficiency has detrimental effects on both MCs and TECs as miR-25 prevents TEC apoptosis by modulating the phosphatase and tensin homolog (PTEN)/Akt pathway and reduces oxidative stress in MCs by targeting NADPH oxidase 4 (Nox4).