CD1D and systemic sclerosis: Furthermore, although we have not directly shown binding of a CL-bound CD1d tetramer to SSc Vδ1+ T cells, the involvement of CD1d lipid-presenting molecules in CL-induced SSc-specific perturbations of γδ T cell subset activation was suggested by the finding that CL + zol activation of SSc Vδ1+ T cells was inhibited by a mAb to CD1d.