As shown in Figure 2A, no significant change of other tested genes was observed at 96 h post transfection even though SOX5 knockdown markedly decreased expression of TNF-α (p = 0.03), MMP-2 (p = 0.01), and MMP-9 (p = 0.003) in RA-FLS. The gene discussed is TNF; the disease is rheumatoid arthritis.