Inhibition of type-I IFN signaling through neutralizing IFN-α antibody (Figure 6E) or fludarabine (Figure 6F) dampened but did not completely block the GF-17- and BMAP-18-mediated ZIKV inhibition, suggesting that GF-17- and BMAP-18-induced IFN signaling is limiting ZIKV infection in the fetal astrocytes. This evidence concerns the gene IFNA1 and Zika virus infectious disease.