In these mice, as in humans, inactivation of the fumarylacetoacetate hydrolase (FAH) gene, which encodes the final enzyme in the pathway for tyrosine catabolism, leads to the accumulation of toxic levels of the upstream tyrosine catabolites maleylacetoacetate and fumarylacetoacetate, eventually causing hepatocyte death, fibrosis, and hepatic failure (238). This evidence concerns the gene FAH and Hepatic failure.