Over the next several years, it gradually emerged that one of Myc’s principle functions, both in normal and cancer cells, was to regulate cell mass and, in doing so, to directly modulate the expression of genes involved in ribosomal biogenesis including ribosomal structural genes, tRNAs, rRNAs, and all three eukaryotic RNA polymerases that control the expression of these genes (100–109). Here, MYC is linked to cancer.