MYCN and neuroblastoma: In other studies using a transgenic mouse model of neuroblastoma driven by the highly related Myc homolog N-Myc, Zirath et al. (196) showed that the treatment of tumor-bearing animals with the small molecule Myc inhibitor 10058-F4 (197), which also binds to and distorts the structure of N-Myc (198), inhibited tumor growth and promoted tumor differentiation as evidenced by neurite outgrowth.