To further understand the role of endogenous Myc in maintaining basal rates of glycolysis and OXPHOS in transformed cells, Graves et al. (158) utilized the conditional, doxycycline-regulatable expression of a short hairpin RNA directed against Myc to silence the oncoprotein’s expression in A549 human small cell lung cancer cells, which normally express high levels of Myc. Here, MYC is linked to small cell lung carcinoma.