ABCB6 and colorectal carcinoma: In particular, the inflammatory state, a condition linked to some cancers, including CRC (Markman and Shiao, 2015), has been shown to affect the pharmacokinetic and pharmacodynamic parameters of various chemotherapeutics by modulating drug metabolic enzymes and ABC/SLC transporters (Cressman et al., 2012; Harvey and Morgan, 2014).