Furthermore, these concentrations were able to inhibit DNMT, MBP, and HDAC enzymatic activity, reactivate methylated-silenced TSGs, induce histone acetylation and alter nucleosome positioning in PCa cell lines (Fang et al., 2007; Wang et al., 2007; Pandey and Gupta, 2009; Majid et al., 2010). This evidence concerns the gene DNMT1 and posterior cortical atrophy.