Additionally, the exposure of PCa cells to hydralazine decreased DNMT1, DNMT3A, and DNMT3B mRNA levels as well as DNMT1 protein levels, which might be linked to the significant decrease in GSTP1, BCL2, and CCND2 promoter methylation levels and concomitant transcript re-expression. The gene discussed is CCND2; the disease is posterior cortical atrophy.