Increased tumor grade (Gleason score ≥ 7) has been associated not only with widespread genome hypomethylation but also with promoter hypermethylation of several individual loci, including ABCB1, APC, GSTP1, PTGS2, PYCARD, RARβ2, and RASSFA1 (Florl et al., 2004; Kang et al., 2004). Here, APC is linked to neoplasm.