SLC22A2 and renal cell carcinoma: A recent report, that evaluated the methylation profile of drug target genes in RCC, demonstrated that 1 μM of 5-aza-2′-deoxycytidine decreased 5-mC content in genomic DNA of Caki-2 cells leading to organic cation transporter 2 (encoded by SLC22A2 gene) re-expression.