Of interest, FN1, which was commonly up-regulated in HCHWA-D and APP-E693Q mice, was also found up-regulated in plasma of both asymptomatic HCHWA-D and PSEN1 mutation carriers (Muenchhoff et al., 2016) and was recently proposed as a blood-based biomarker for AD (Long et al., 2016). This evidence concerns the gene PSEN1 and Alzheimer disease.