Clinical studies reveal elevated serum levels of inflammatory cytokines [particularly TNF-a (Álvarez et al., 2007) and IL-6 (Hüll et al., 1996)] in patients with AD and reduction of AD risk with long-term use of COX-inhibiting non-steroidal anti-inflammatory drugs (NSAIDs) (In t’ Veld et al., 2001). This evidence concerns the gene TNF and Alzheimer disease.