The aim of our study includes two aspects (Figure 1): (1) to compare the SHP2 expression in thyroid tumour tissue and that in normal tissue by IHC analysis and (2) to develop SHP2-targeted phase-changeable PLGA nanoparticles as a novel molecular probe for ultrasound imaging, providing a practicable method for thyroid cancer detection. The gene discussed is PTPN11; the disease is thyroid gland carcinoma.