To determine the role of US28 signaling in GBM in a clinically more relevant context, U251 GBM cells (Fig. 7a) and GBM48 primary GBM cells (Fig. 7b) were infected with the clinically relevant HCMV Merlin strain and subsequently treated with either bivalent US28-Nb or Irr-Nb. Here, NF2 is linked to glioblastoma.