Subsequently, we compared GAS7b expression levels between the two age groups of patients with wild-type and mutated p53. In both younger and older age groups, we found that patients with p53 mutations had significantly lower GAS7b levels than patients with wild-type p53 (Fig. 6d), suggesting that p53 mutation was associated with downregulation of GAS7b expression in breast cancer, and this is in agreement with the transcriptional regulation of GAS7 by p53 described above. The gene discussed is TP53; the disease is breast cancer.