This has been observed in the case of the recurrent c.1205G>A, p.(Arg402His) variant in TUBA1A causing classic lissencephaly, and the c.790C>T, p.(Arg264Cys) variant in the same gene associated with central pachygyria [6, 11, 34, 35]. This evidence concerns the gene TUBA1A and Lissencephaly.