For example, inhibition of IKKα prolongs survival and suppresses the occurrence of metastatic diseases in models of mammary, prostate, and colorectal cancers38–42, whereas, IKKα controls metastasis in breast and prostate cancers and is required for mammary tumorigenesis through expansion of tumor-initiating cells39–41. The gene discussed is CHUK; the disease is metastatic neoplasm.