In the multivariate Cox regression model, our data further confirmed that KIF4A expression remained an independent significant prognostic biomarker for OS (P = 0.003, hazard ratio (HR) = 2.12, 95% confidence interval (CI) = 1.30–3.47) and DFS (P = 0.007, HR = 2.60, 95% CI = 1.29–5.36) for the CRC patients after adjusting for TNM stage, differentiate type, distant metastasis, age, and gender (Table 3). This evidence concerns the gene KIF4A and colorectal carcinoma.