We elucidated the novel molecular mechanism underlying the effects of ECD in cancer progression, as we determined that ECD promotes invasion and metastasis by stabilizing hnRNP F. We further demonstrated that ECD competitively bound to hnRNP F through the N-terminal STG1 domain to prevent ZFP91-mediated hnRNP F ubiquitination and degradation. Here, ZFP91 is linked to cancer.