ZFP91 and cancer: We showed that ECD promoted GC metastasis and invasion by stabilizing hnRNP F. We found that ECD bound to hnRNP F to prevent E3 ligase ZFP91 from interacting with hnRNP F, thus blocking ZFP91-mediated hnRNP F polyubiquitination at Lys 185 and increasing hnRNP F protein levels to promote cancer metastasis and invasion.