CD40LG and malaria: To establish whether complement also enhanced the function of human antibodies that contain antibodies to CSP and other Plasmodium antigens, we tested purified antibodies (including IgG and IgM) from a pool of malaria-exposed Kenyan adults (n = 19 samples, Additional file 1: Figure S5) and malaria-naïve Melbourne donors, and quantified P. falciparum sporozoite transversal (Fig. 4c).