Thesefindings could also potentially indicate a source of elevated peripheralinflammation in AD as miR-155 is NF-κB sensitive and also acts to increase thetranscription of NF-κB, which in turn allows for increasing levels ofinflammation and PIC production by activated T cells in a positive feedback loop[121, 122]. This evidence concerns the gene NFKB1 and Alzheimer disease.