Briefly, two independent research teams have reported thepresence of a hypermethylated region in ANK1and changes in ANK1 mRNA levels are associatedwith the geographical extent and overall burden of neuropathology in theentorhinal cortex, prefrontal cortex and superior temporal gyrus in symptomaticand pre-symptomatic AD patients in post mortem studies [65, 66]. The gene discussed is ANK1; the disease is Alzheimer disease.