APOE and Alzheimer disease: There is also evidence that,compared with age- and sex-matched controls, AD patients carrying both the APOE ε4 allele and the H63D polymorphism of thehemochromatosis protein-related class I-like major histocompatibility gene HFE are significantly more susceptible to earlierdevelopment of AD than those carrying only one of these mutations [57]; reviewed by [58].