TREM-2 activity is also intimately connected with microglialphagocytosis as discussed above and exerts its signalling effects via amulti-receptor complex with signalling adaptor molecule DNAX-activating protein of12 kDa (DAP12) and dysfunction of this signalling axis may play a role in theimpaired microglial phagocytosis repeatedly reported in AD brains. Here, TREM2 is linked to Alzheimer disease.