Hence, NF-κB- and AP-1-induced activation of JNKsignalling, and consequent upregulation of BACE1 and PSEN1 (which encodesPS1), likely could lead to increased Aβ production and possibly an exacerbation ofcognitive decline and neuronal apoptosis in AD [16, 200]. The gene discussed is PSEN1; the disease is Alzheimer disease.