NOS2 and Alzheimer disease: These findings are consistent with those of the work of other authorswho have produced evidence suggesting that such microglial activation and subsequentproduction of cytokines, chemokines, nitric oxide (NO), prostaglandins, reactiveoxygen species (ROS), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2(COX-2), and other mediators of inflammation and neurotoxicity also play a criticalrole in AD pathogenesis [142–144].