As mentioned above, a recent meta-analysis concluded that increasedmethylation of the TREM2 promoter regionappears to be an invariant feature in the brains of AD patients independently ofage and sex [64]; furthermore, thisincrease in methylation is associated with a higher level of TREM-2 activity inthe brains of AD patients compared with healthy age- and sex-matched controls[69]. The gene discussed is TREM2; the disease is Alzheimer disease.