These findings, allied to those discussed above, may wellbe important from the perspective of AD pathogenesis as the association betweenperipherally increased PICs and TREM-2 and increased AD risk and/or severitycould be explained by the initiation and/or exacerbation of microglialactivation, either as a result of high peripheral PIC levels and/or the egressof activated Th1 and/or Th17 cells into the CNS. The gene discussed is SLC25A3; the disease is Alzheimer disease.