This is significant given that a recent study has reportedreduced levels of TOMM40 in the brains of AD patients which correlated with theextent of cognitive decline [229]and the results of a large meta-analysis involving 10,358 AD cases and 18,157healthy controls which concluded that the TOMM40rs2075650 polymorphism was associated with an increased risk ofdisease development (odds ratio 4.178) [230]. The gene discussed is TOMM40; the disease is Alzheimer disease.