It isnoteworthy that MTOR expression is normallyincreasingly inhibited in the ageing brain [298, 299], andhence the existence of elevated mTOR activity in the hippocampus of AD patientscould be a factor underpinning dysfunctional autophagic lysosomal clearance inthat region of the brain, as discussed above. The gene discussed is MTOR; the disease is Alzheimer disease.