For example, high intracellular cholesterol level, a risk factor for development of Alzheimer's disease, has been shown to affect APP secretion, post‐translational modification and intracellular trafficking.15 Although the molecular determinants for Aβ mitochondrial import are not known, mitochondrial protein translocase also participates in the import of Aβ peptide16 suggesting that reduction in APP and Aβ mis‐targeting can promote neuronal survival under AD conditions. This evidence concerns the gene APP and early-onset autosomal dominant Alzheimer disease.