To validate diagnosis, we recommend to include blood differential (cytopenia, eosinophilia), ferritin, soluble IL2R, fibrinogen, and triglycerides in addition to the routine ICU lab admission panel in cancer patients with sepsis or sepsis-like syndromes in whom there is no apparent focus of sepsis [90, 91] (see Table 6 for HLH diagnostic criteria). The gene discussed is IL2RA; the disease is Sepsis.