In the present study, we therefore perorally challenged conventionally colonized IL-10−/− suffering from chronic colitis with a clinical MDR Psae isolate and assessed intestinal colonization properties of the opportunistic pathogen, shifts in gut microbiota composition, Psae-induced intestinal and systemic pro-inflammatory infectious sequelae, and translocation of viable bacteria to extra-intestinal including systemic compartments. This evidence concerns the gene IL10 and Chronic colitis.