IRS1 and Familial prostate cancer: Prostate cancer signalling was among the top ten canonical pathways consisting of 8 deregulated target genes (highlighted in purple) i.e. FGFR3, IRS1, SOS2, HSP90AA1, KRAS, CDKN1B, CCND1 and PTEN of miR-152-3p (−log p = 5.75) (Fig. 6) where FGFR3 and IRS1 are closely related to PI3K and hence shown as a group.