PTEN and Familial prostate cancer: Furthermore, Oncomine data analysis of these 8 genes showed significant upregulation of CCND1 (p = 9.88E-6), FGFR3 (p = 0.002) and PTEN (p = 0.022) in prostate carcinoma (N = 65) compared to normal (N = 23) tissues in the Yu Prostate Cancer Dataset (Supplementary Figure S7a,b), however, five i.e. HSP90AA1 (p = 7.92E-14), CDKN1B (p = 1.67E-12), CCND1 (p = 4.50E-9), PTEN (p = 5.70E-6) and KRAS (p = 0.021) out of 8 target genes were significantly upregulated during prostate cancer metastasis (Supplementary Figure S7c).