To investigate the impacts of NAT10 inhibition in vivo, and as the main cause of death in HGPS patients is due to heart dysfunction, we performed global gene-expression analyses on tissues derived from hearts of LmnaG609G/G609GNat10+/− and Remodelin-treated LmnaG609G/G609G mice, compared to their respective controls (Supplementary Data 5). Here, NAT10 is linked to Hutchinson-Gilford progeria syndrome.