Treatment of the P3X63ag8.653 plasmacytoma cell line with the EZH2 inhibitor GSK34313 resulted in a dose dependent decrease in global H3K27me3 levels but not other trimethylated residues such as H3K4me3 or total histone H3 (Supplementary Fig. 4c) that is consistent with previous observations13, 15. The gene discussed is EZH2; the disease is plasmacytoma.