VEGFA and neoplasm: Shear stress-related effects during exercise are of relatively greater impact for the macrovasculature (and should thus spare the tumor microvasculature), even though restores the endothelial response to VEGF and improves endothelium-dependent vasodilatation in epicardial coronary vessels and in resistance vessels.89, 90, 91 Exercise has the additional advantage of improving the CV reserve in general as well as alerting to any of its potential impairments much sooner than detected by resting assessments.