It was further recommended not to start VEGF inhibitor therapy in patients with unstable or poorly controlled angina/myocardial ischemia at baseline or a recent myocardial or arterial thrombotic event (and neither in those with uncontrolled heart failure, uncontrolled arrhythmia, significant QTc prolongation, and uncontrolled hypertension). Here, VEGFA is linked to cardiac arrhythmia.