Accordingly, for patients with high-CV risk, especially those with atherosclerotic disease and particularly anyone with a history of clinically evident CAD, CVD, and peripheral arterial disease should be on a baby aspirin, high-dose statin, possibly in combination with ACE inhibitor and/or amlodipine therapy and should be asked to exercise routinely (goal for aerobic exercise is 3–5 d/wk, 150+ min/wk of moderate intensity). The gene discussed is ACE; the disease is peripheral arterial disease.