EDNRA and hypertensive disorder: In agreement with a lesser role of the renin-angiotensin system in the mechanism of VSP inhibitor-induced hypertension, captopril was effective in lowering lower (10 mmHg) but not higher (35–50 mmHg) degrees of blood pressure elevations in animal models.53, 54 Comparable to dual ETa/ETb receptor blockade, captopril did prevent renal structural changes and is a preferred option in patients with proteinuria.