Furthermore, at low concentrations, they are pro-angiogenic, whereas at high concentrations, they are anti-angiogenic.73, 83 These dual dynamics have been recapitulated in tumor models, adding to the increasing view of anticancer effects of statins.84, 85 Accordingly, there should be a low threshold for the use of high-dose statin therapy in cancer patients who are to or are already undergoing VEGF inhibitor therapy and are at CV risk. Here, VEGFA is linked to neoplasm.