The nucleoside analogue gemcitabine is not effluxed by the multidrug resistance gene-1–P glycoprotein (MDR-1–Pgp), which is overexpressed in some peripheral T-cell lymphomas7, 8 on the tumour cells, residual lymphocytes, or in the endothelium8 and has shown activity both as monotherapy9, 10, 11 and in combination with platinum and steroids12, 13, 14, 15, 16, 17, 18, 19, 20 in patients with relapsed or refractory peripheral T-cell lymphoma. This evidence concerns the gene ABCB1 and peripheral T-cell lymphoma, not otherwise specified.