In cancer cells, the extracellular domain serves as a receptor for adhesion proteins and growth factors in the extracellular matrix (ECM) [4], and the cytoplasmic tail is linked to the cytoskeleton and cellular signaling pathways, such as focal adhesion kinase (FAK) and Src family kinases [5], mediating tumor cell attachment, invasion, and migration, as well as tumor angiogenesis [1, 6–8]. This evidence concerns the gene PTK2 and cancer.