APOE can be an important constituent of High Density Lipoprotein (HDL) particles, where formation partly depends on the export by ABCA1 and ABCG1. However, here our results are in disagreement with other in vivo reports, which associates low levels of ABCA1 and low levels of circulating HDL with prostate cancer [58, 59]. Here, APOE is linked to Familial prostate cancer.